Epigenetics in the Genome
Epigenetics is the dynamic and heritable modifications to the genome that occur independently of DNA sequence.
Changes to the epigenome — DNA methylation, histone modifications, and the chromatin state — influence what genes are expressed.
Aberrant epigenetic alterations can lead to inappropriate onset of genetic expressions and promote tumorigenesis. As the epigenetic modifiers are reversible, they are becoming promising targets in multiple cancer therapies.
More and more research has found that many diseases have overlapping epigenetic signatures.
The Revolutionizing Potential of Epigenetics
Sequencing the epigenome has been a slow, expensive, multi-step and indirect/error prone process.
Only Armonica can provide the direct assessment of epigenetic modifications affording the accuracy needed for actionable results.
There are over 4000 recent publications on the epigenetics of cancer alone and over 39 epigenetic drugs currently in clinical trials.