More data
Sequence all genomic variants including epigenetic modifications
Better results
Directly sequence long sections of DNA (>50 kbp) with high accuracy
Less complexity
Minimal Sample Prep and Reduced Reagent Consumption
1
Compared to the ionic sensing of other nanopore methods, SERS-based detection provides direct structural information, enabling distinction of individual nucleotides and epigenetic, isotopic and other chemical modification markers
2
Enhanced Raman Spectroscopy (SERS) facilitates the direct measurement of the actual physical properties of in-situ nucleotides in nucleic acids.
3
1) Takes a complete spectral “Fingerprint” of each nucleotide and detects critical DNA modifications with distinct spectra - Epigenetic Modifications Directly Measured - example
dCTP, 5m-dCT, 5hm-dCTP.
Why SERs Raman?
Direct Long-Read Epigenetic Sequencing Platform
Addresses the limitations of today’s sequencing technologies to advance the promise of precision medicine.