Detecting what others cannot see
We are at the forefront of genomic innovation with a vision that extends beyond the conventional boundaries of science and medicine.
Our pioneering technology aims to address significant gaps in genomics research, diagnostics, therapeutics and drug development.
Our novel method identifies genomic data and modifications not accessible with other commercial technologies.
Our unique platform does not require DNA amplification, labels or library preparation.
Research & Technology
We leverage machine learning technology to ensure precise data analysis and research.
Key advancements
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Developed and demonstrated of easily manufacturable (optical lithography) metamaterial/plasmonic nanostructures with sensitivity sufficient for non-resonant SERS single nucleotide detection.
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First bi-analyte demonstration of non-resonant single nucleotide SERS sensitivity with these nanostructures.
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Embedding of metamaterial/plasmonic nanostructures within nanochannel architectures.
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Experimental demonstration of single nucleotide detection in nanochannels with embedded enhancement structures for both dsDNA and ssDNA.
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Demonstration of electric field control (flossing) of ssDNA in the nanochannels.
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Transport of ~ 7 kbase ssDNA in nanochannels (and 50k lambda dsDNA)
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Nanochannels with enhancement structures
A platform of nanochannels (~40nm dimension) with embedded enhancement structures to perform Surface Enhanced Raman Spectroscopy (SERS). This approach provides scalable technology that can allow massively parallel detection of single nucleotide sensitivity and resolution. The fabrication currently performed by e-beam and optical lithography is easily transferred to industry-standard optical or nanoimprint lithography methods found in large silicon foundries.
Compared to the ionic sensing of other nanopore methods, SERS-based detection provides direct structural information, enabling the distinction of individual nucleotides and epigenetic, isotopic, and other chemical modification markers.
Armonica Tech., San Diego laboratories
Armonica’s Center on the University of New Mexico campus
Center for High Technology Materials (CHTM/UNM) Facilities
Center for Integrated Nanotechnologies (CINT: DOE User Facility, Sandia and Los Alamos National Laboratories)
UCSD Nano3 facility at the University of California-San Diego
Problem
DNA is the source code for all living things and reading DNA is fundamental. Current methods to read DNA (aka sequencing) often miss critical data. Market sequencing platforms require DNA to be amplified, and important genomic markers are lost in this process.
Amplification causes copying errors and loss of critical epigenetic information, adding time, cost, and complexity. In addition, these technologies also only read very small DNA fragments of DNA and contribute to significant gaps in diagnostic capabilities.
Detection of large structural variants, long range epigenetic mapping, and de novo genome assembly
Sequencing of ultra-long, native nucleic acid molecules at single base resolution
No labeling or amplification of target nucleic acid is required, and sequence is read in real-time
Detection of large structural variants, long range epigenetic mapping, and de novo genome assembly