A fundamental issue for pore-based sequencing techniques is the speed of nucleic acid translocation. Our “tortuous nanopore” platform provides an elegant, inexpensive and manufacturable solution to this challenge.
Tortuous nanopores of silica nanoparticles on glass naturally control the speed of nucleic acid transport without the need for preparing a sample library or adding biological constructs.
Surface-enhanced Raman spectroscopy (SERS) readout provides direct structural information, enabling distinction of individual nucleotides and epigenetic marks.
Because our optical readout mechanism has massively parallel capabilities, the resultant output will provide high accuracy and fidelity, combined with a very high throughput.